Reaction: LTA4 is converted to LTC4 by LTC4S
- in pathway: Synthesis of Leukotrienes (LT) and Eoxins (EX)
Leukotriene A4 conjugates with reduced glutathione (GSH) to produce leukotriene C4 (LTC4). This conjugation is mediated by the homodimeric, perinuclear membrane-bound enzyme leukotriene C4 synthase (LTC4S) (Lam et al. 1994, Welsch et al. 1994). LTC4S differs from cytosolic and microsomal GSH-S-transferases by having a very narrow substrate specificity and the inability to conjugate xenobiotics.
Reaction - small molecule participants:
LTC4 [cytosol]
GSH [cytosol]
LTA4 [cytosol]
Reactome.org reaction link: R-HSA-266050
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Reaction input - small molecules:
glutathionate(1-)
leukotriene A4
Reaction output - small molecules:
leukotriene C4
Reactome.org link: R-HSA-266050