Reaction: 5S-HpETE is dehydrated to LTA4 by ALOX5
- in pathway: Synthesis of Leukotrienes (LT) and Eoxins (EX)
In the second step of the formation of leukotriene A4 (LTA4) from arachidonic acid, arachidonate 5-lipoxygenase (ALOX5) converts 5S-hydroperoxyeicosatetranoic acid (5S-HpETE) to an allylic epoxide, leukotriene A4 (LTA4) (Rouzer et al. 1988, Rouzer & Samuelsson 1987, Rouzer et al. 1986).
Reaction - small molecule participants:
H2O [cytosol]
LTA4 [cytosol]
5S-HpETE [cytosol]
H2O [cytosol]
LTA4 [cytosol]
5S-HpETE [cytosol]
Reactome.org reaction link: R-HSA-266051
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Reaction input - small molecules:
5(S)-HPETE
5(S)-HPETE
Reaction output - small molecules:
water
leukotriene A4
water
leukotriene A4
Reactome.org link: R-HSA-266051