Reaction: LTA4 is hydolysed to LTB4 by LTA4H
- in pathway: Synthesis of Leukotrienes (LT) and Eoxins (EX)
Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that catalyzes the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) to the dihydroxy acid leukotriene B4 (LTB4) (Radmark et al. 1984, McGee & Fitzpatrick 1985).
Reaction - small molecule participants:
LTB4 [cytosol]
H2O [cytosol]
LTA4 [cytosol]
Reactome.org reaction link: R-HSA-266072
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Reaction input - small molecules:
water
leukotriene A4
Reaction output - small molecules:
leukotriene B4
Reactome.org link: R-HSA-266072