Reaction: TPCN1/2 transport lysosomal Ca2+ to cytosol
- in pathway: Stimuli-sensing channels
Calcium (Ca2+) can be mobilised from intracellular stores by the presence of nicotinic acid adenine dinucleotide phosphate (NAADP). Two pore calcium channel proteins 1 and 2 (TPCN1 and 2) are expressed on endosomal (not shown here) and lysosomal membranes and mediate the mobilization of Ca2+ from these organelles when activated by NAADP (Brailoiu et al. 2009, Calcraft et al. 2009).
Reaction - small molecule participants:
Ca2+ [cytosol]
Ca2+ [lysosomal lumen]
Reactome.org reaction link: R-HSA-2685505
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
calcium(2+)
Reactome.org link: R-HSA-2685505