Reaction: CLCN4/5/6 exchange Cl- for H+
- in pathway: Stimuli-sensing channels
The H+/Cl- exchange transporters CLCN4 (Kawasaki et al. 1999, Zdebik et al. 2008), CLCN5 (Zdebik et al. 2008) and CLCN6 (Neagoe et al. 2010) mediate the exchange of endosomal Cl- for cytosolic H+ across endosomal membranes, contributing to the acidification of endosomes.
Reaction - small molecule participants:
H+ [endosome lumen]
Cl- [cytosol]
H+ [cytosol]
Cl- [endosome lumen]
Reactome.org reaction link: R-HSA-2730692
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Reaction input - small molecules:
hydron
chloride
Reaction output - small molecules:
hydron
chloride
Reactome.org link: R-HSA-2730692