Reaction: CLCN3 exchanges Cl- for H+
- in pathway: Stimuli-sensing channels
The H+/Cl- exchange transporter CLCN3 (Borsani et al. 1995) mediates the exchange of endosomal Cl- for cytosolic H+ across late endosomal membranes, contributing to the acidification of endosomes. The activity of CLCN3 is inferred from experiments in mice (Stobrawa et al. 2001, Hara-Chikuma et al. 2005).
Reaction - small molecule participants:
H+ [late endosome lumen]
Cl- [cytosol]
H+ [cytosol]
Cl- [late endosome lumen]
Reactome.org reaction link: R-HSA-2731002
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Reaction input - small molecules:
hydron
chloride
Reaction output - small molecules:
hydron
chloride
Reactome.org link: R-HSA-2731002