Reaction: TTYH2/3 transport cytosolic Cl- to extracellular region
- in pathway: Stimuli-sensing channels
Human homologues 2 and 3 (TTYH2 and 3) mediate the efflux of Cl- from cells in response to the increase in intracellular Ca2+ levels (Suzuki & Mizuno 2004, Suzuki 2006). All CLCAs contain a consensus cleavage motif which is recognised by an internal zincin metalloprotease domain within the N terminus. Self-proteolysis within the secretory pathway yields N- and C-terminal fragments, a step critical for CLCA activation of calcium-activated chloride channels (CaCCs) mediated through the N-terminal fragment (Yurtsever et al. 2012).
Reaction - small molecule participants:
Cl- [extracellular region]
Cl- [cytosol]
Reactome.org reaction link: R-HSA-2744242
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Reaction input - small molecules:
chloride
Reaction output - small molecules:
chloride
Reactome.org link: R-HSA-2744242