Reaction: BESTs transport cytosolic HCO3- to extracellular region
- in pathway: Stimuli-sensing channels
Many Cl- channels such as CFTR, ClC, CaCC, and ligand-gated anion channels are permeable to bicarbonate (HCO3-) which is an important anion in the regulation of pH. Many tissues, including retinal pigment epithelium (RPE), utilize HCO3- transporters to mediate transport of HCO3-. Bestrophns 1-4 (BEST1-4, aka vitelliform macular dystrophy proteins) have high permeability to HCO3- (Hu & Hartzell 2008). Defective BEST1 may play a role in macular degeneration in the eye due to impaired HCO3- and Cl- conductance (Hu & Hartzell 2008).
Reaction - small molecule participants:
HCO3- [extracellular region]
HCO3- [cytosol]
Reactome.org reaction link: R-HSA-2752067
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Reaction input - small molecules:
hydrogencarbonate
Reaction output - small molecules:
hydrogencarbonate
Reactome.org link: R-HSA-2752067