Reaction: Hydrolysis of internal thioester in C4b
- in pathway: Regulation of Complement cascade
Cleavage of C4 exposes a highly reactive thioester bond on the C4b molecule. The thioester bond is rapidly inactivated by hydrolysis if C4b does not bind to the target cell surface [Sepp A et al 1993].
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-2855047
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-2855047