Reaction: Ficolin-2 binds to molecular patterns on the target cell surface
Human ficolin-2 (L-ficolin, P35, FCN2) is synthesised in the liver and secreted into the bloodstream where it recognizes various capsulated bacteria and exhibits binding specificity for diverse ligands such as lipoteichoic acid, 1,3-beta-d-glucan and acetylated compounds (Lynch et al. 2004, Aoyagi et al. 2008, Ma et al. 2004, Garlatti et al. 2007, Gout et al. 2010). Ficolin-2 also binds to apoptotic HL60, U937 and Jurkat cells (Kuraya et al. 2005).
Reaction - small molecule participants:
Ca2+ [extracellular region]
Reactome.org reaction link: R-HSA-2855054
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Reaction input - small molecules:
calcium(2+)
Reaction output - small molecules:
Reactome.org link: R-HSA-2855054