Reaction: Conjugation of SUMO1 to UBA2:SAE1
- in pathway: SUMO is conjugated to E1 (UBA2:SAE1)
The UBA2:SAE1 complex catalyzes the formation of a thioester bond between SUMO1 and cysteine-173 of UBA2 (Desterro et al. 1999, Okuma et al. 1999, Werner et al. 2009, Olsen et al. 2010, Wang and Chen 2010). ATP reacts with the C-terminal glycine residue of SUMO1 to yield pyrophosphate and a transient intermediate, SUMO1 adenylate, which then reacts with the thiol group of the cysteine residue on UBA2.
Reaction - small molecule participants:
AMP [nucleoplasm]
PPi [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-2990833
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
adenosine 5'-monophosphate(2-)
diphosphate(3-)
Reactome.org link: R-HSA-2990833