Reaction: TCN2 binds RCbl in the circulation
- in pathway: Transport of RCbl within the body
Transcobalamin (TCN2, TC) is secreted by endothelial cells into plasma where it binds cobalamins (RCbl) and mediates their uptake into cells throughout the body. TCN1 (aka haptocorrin) is also present in the blood and binds RCbl efficiently (Johnston et al. 1989, Quadros et al. 1986, Wuerges et al. 2006), but the TCN1:RCbl complex is not readily taken up from the blood by most cells and and Alam et al. (2016) have suggested that the physiological role of TCN1 is to bind and sequester Cbl-like corenoids to prevent their tissue uptake.
Reaction - small molecule participants:
RCbl [extracellular region]
Reactome.org reaction link: R-HSA-3000074
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Reaction input - small molecules:
R-cob(III)alamin
Reaction output - small molecules:
Reactome.org link: R-HSA-3000074