Reaction: Activated ERKs phosphorylate ERF
- in pathway: Oncogene Induced Senescence
Activated ERKs (ERK1 i.e. MAPK3 and ERK2 i.e. MAPK1) phosphorylate ERF on threonine residue T526 and possibly other sites. The threonine T526 seems to be the dominant phosphorylation site and its functional relevance has been established (Sgouras et al. 1995, Le Gallic et al. 2004).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-3209160
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-3209160