Reaction: MAPKAPK5 phosphorylates TP53
- in pathway: Regulation of TP53 Activity through Phosphorylation
Activated MAPKAPK5 (PRAK) phosphorylates TP53 (p53) on serine residue S37, thereby activating it. MAPKAPK5-mediated phosphorylation of TP53 promotes growth arrest and senescence induced by oncogenic RAS, but is not needed for TP53-dependent growth arrest in response to DNA damage (Sun et al. 2007).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-3239014
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-3239014