Reaction: STING binds cyclic GMP-AMP
- in pathway: STING mediated induction of host immune responses
Direct binding assays with radiolabeled substrate showed that the association of STING protein (residues 139-379) with [32P]-cGAMP was inhibited in the presence of competing cold cGAMP, c-di-GMP or c-di-AMP, suggesting that the cGAMP binding sites on STING might overlap with those that interact with c-di-GMP and c-di-AMP (Wu J et al.2013). Indeed, mutations of several residues that were shown to participate in the binding of STING to c-di-GMP, including S161Y, Y240S and N242A, also impaired the binding of STING to cGAMP (Yin Q et al. 2012; Wu J et al.2013). Structural study revealed that cGAMP generated by cGAS contains G(2',5')pA and A(3',5')pG phosphodiester linkages, which is distinct from bacterial 3',5' cyclic dinucleotides (Gao P et al. 2013).
Reaction - small molecule participants:
c-GMP-AMP [cytosol]
Reactome.org reaction link: R-HSA-3244643
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Reaction input - small molecules:
c-GMP-AMP(2-)
Reaction output - small molecules:
Reactome.org link: R-HSA-3244643