Reaction: TCN1 binds correnoids in the circulation
- in pathway: Transport of RCbl within the body
The glycoprotein transcobalamin 1 (TCN1 aka haptocorrin, HC, TCI) binds correnoids, biologically inactive analogs of cobalamin (Cbl). The resulting complexes are cleared rapidly from the blood by hepatocytes and excreted in the urine and bile (Kolhouse & Allen 1977). Structural studies by Furger et al. (2013) and Alam et al. (2016) suggest mechanisms for the differential binding of Cbl over other correnoids by TCN2 in contrast to the broad correnoid specificity of TCN1, consistent with a role for the latter in scavenging and mediating the hepatobiliary excretion of corrinoids.
Reaction - small molecule participants:
correnoid [extracellular region]
Reactome.org reaction link: R-HSA-3245898
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Reaction input - small molecules:
corrinoid
Reaction output - small molecules:
Reactome.org link: R-HSA-3245898