Reaction: G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous)
- in pathway: Gluconeogenesis
Glucose-6-phosphatase 3 (G6PC3) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate (G6) to glucose (Glc) and orthophosphate (Pi). This reaction is essentially irreversible (Guionie et al. 2003; Ghosh et al. 2004). In the body, this enzyme is ubiquitously expressed; mutations that inactivate it are associated with severe congenital neutropenia (but not with fasting hypoglycemia or lactic acidemia) (Boztug et al. 2009).
Reaction - small molecule participants:
Pi [endoplasmic reticulum lumen]
Glc [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
G6P [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-3262512
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Reaction input - small molecules:
water
alpha-D-glucose 6-phosphate(2-)
Reaction output - small molecules:
hydrogenphosphate
alpha-D-glucose
Reactome.org link: R-HSA-3262512