Reaction: G6PC2 hydrolyzes G6P to form Glc and Pi (islet)
- in pathway: Gluconeogenesis
G6PC2 (Glucose-6-phosphatase 2), associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose (Glc) and orthophosphate (Pi). This reaction is essentially irreversible. This enzyme is expressed in islet cells of the pancreas (Petrolonis et al. 2004).
Reaction - small molecule participants:
Pi [endoplasmic reticulum lumen]
Glc [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
G6P [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-3266566
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Reaction input - small molecules:
water
alpha-D-glucose 6-phosphate(2-)
Reaction output - small molecules:
hydrogenphosphate
alpha-D-glucose
Reactome.org link: R-HSA-3266566