Reaction: GPR31 is a receptor for 12(S)-HETE
- in pathway: Free fatty acid receptors
GPR31 binds with high affinity the 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)-HETE). 12-(S)-HETE/GPR31-mediated ERK1/2 activation was inhibited by pertussis toxin, suggesting that the involvement of the G-alpha-i/o heterotrimeric G proteins.
Reaction - small molecule participants:
12(S)-HETE [extracellular region]
Reactome.org reaction link: R-HSA-3296304
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Reaction input - small molecules:
12(S)-HETE
Reaction output - small molecules:
Reactome.org link: R-HSA-3296304