Reaction: SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)
- in pathway: Detoxification of Reactive Oxygen Species
Cu-Zn superoxide dismutase (SOD1), originally known as erythrocuprein, catalyzes the reaction of two molecules of superoxide (O2.-) to yield one molecule of hydrogen peroxide (H2O2) and one molecule of oxygen (O2) (McCord and Fridovich 1969 assayed both bovine and human Cu-Zn superoxide dismutase, the human sample provided by Carrico and Deutsch). Diffusion of hydrogen peroxide, the product of SOD1, across the cytosol is limited (Mishina et al. 2011)
Reaction - small molecule participants:
O2 [cytosol]
H2O2 [cytosol]
H+ [cytosol]
O2.- [cytosol]
Reactome.org reaction link: R-HSA-3299691
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Reaction input - small molecules:
hydron
superoxide
Reaction output - small molecules:
dioxygen
hydrogen peroxide
Reactome.org link: R-HSA-3299691