Reaction: GSTK1 dimer transfers GS from GSH to CDNB
- in pathway: Glutathione conjugation
Glutathione S-transferase Kappa isozyme (GSTK1) is widely expressed in human tissues and exists as a dimer in mitochondria and peroxisomes. It has high activity towards aryl halides such as the model substrate 1-chloro-2,4-dinitrobenzene (CDNB) to which it can conjugate with glutathionate (GS-) from glutathione (GSH) (Morel et al. 2004). Mouse, rat and human possess only one GST Kappa isozyme.
Reaction - small molecule participants:
HCl [mitochondrial matrix]
DNPSG [mitochondrial matrix]
GSH [mitochondrial matrix]
CDNB [mitochondrial matrix]
Reactome.org reaction link: R-HSA-3301943
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Reaction input - small molecules:
glutathione
1-chloro-2,4-dinitrobenzene
Reaction output - small molecules:
hydrogen chloride
S-(2,4-dinitrophenyl)glutathione(1-)
Reactome.org link: R-HSA-3301943