Reaction: PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
- in pathway: Detoxification of Reactive Oxygen Species
Peroxiredoxin 3 (PRDX3) and PRDX5 in the mitochondrial matrix reduce hydrogen peroxide (H2O2) with thioredoxin to yield oxidized thioredoxin and water (Yamashita et al. 1999, Knoops et al. 1999, Cao et al. 2007, Nagy et al. 2011). Reduced PRDX5 is a monomer (Declercq et al. 2001) and oxidized PRDX5 is a dimer (Evrard et al. 2004) therefore the enzyme may cycle between states.
Reaction - small molecule participants:
H2O [mitochondrial matrix]
H2O2 [mitochondrial matrix]
Reactome.org reaction link: R-HSA-3322995
======
Reaction input - small molecules:
hydrogen peroxide
Reaction output - small molecules:
water
Reactome.org link: R-HSA-3322995