Reaction: GPX7,8 catalyze peroxidation of P4HB (PDI)
- in pathway: Detoxification of Reactive Oxygen Species
Glutathione peroxidase 7 (GPX7) and GPX8 are atypical glutathione peroxidases that catalyze the peroxidation of protein disulfide isomerases, such as PDI (P4HB) (Nguyen et al. 2011 and inferred from mouse in Bosello-Travain et al. 2013). GPX7 and GPX8 are each able to form heterodimers with the sulfhydryl oxidase ERO1alpha (ERO1L) in the endoplasmic reticulum lumen. It is hypothesized that GPX7 and GPX8 use hydrogen peroxide produced by ERO1L.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
H2O2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-3341296
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Reaction input - small molecules:
hydrogen peroxide
Reaction output - small molecules:
water
Reactome.org link: R-HSA-3341296