Reaction: KAT5 HAT complex acetylates TCF4 gene at histone H4
TIP49, TRRAP, TCF7L2 (TCF4) and KAT5 are present at the ITF-2 promoter in vivo in HEK293 cells as assessed by ChIP. Expression of a dominant negative form of TIP49 in rat epithelial cells is associated with a decrease in both histone H4 acetylation at the ITF-2 promoter and in ITF-2 gene expression. These results suggest that a TIP49-containing HAT complex may play a role in promoting WNT-responsive ITF-2 expression, although more functional studies will be required to elucidate the mechanism (Feng et al, 2003).
Reaction - small molecule participants:
CoA-SH [nucleoplasm]
Ac-CoA [nucleoplasm]
Reactome.org reaction link: R-HSA-3451147
======
Reaction input - small molecules:
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-3451147