Reaction: VD3 translocates from extracellular region to ER membrane
- in pathway: Vitamin D (calciferol) metabolism
Once vitamin D3 (VD3) is released from vitamin D binding protein (GC, DBP), it translocates from the extracellular region to the ER membrane, becoming available for hydroxylation by the microsomal enzyme CYP2R1 (Shinkyo et al. 2004).
Reaction - small molecule participants:
VD3 [endoplasmic reticulum membrane]
VD3 [extracellular region]
Reactome.org reaction link: R-HSA-350147
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Reaction input - small molecules:
calciol
Reaction output - small molecules:
calciol
Reactome.org link: R-HSA-350147