Reaction: Iodide is organified
- in pathway: Thyroxine biosynthesis
The first step in the biogenesis of thyroid hormones is the oxidation of iodide (I-) by H2O2/peroxidase after being taken up by the thyroid gland. This event is known as organification.
Reaction - small molecule participants:
H2O [extracellular region]
I2 [extracellular region]
NADP+ [extracellular region]
H+ [extracellular region]
NADPH [extracellular region]
I- [extracellular region]
H2O2 [extracellular region]
Reactome.org reaction link: R-HSA-350901
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Reaction input - small molecules:
hydron
NADPH
iodide
hydrogen peroxide
Reaction output - small molecules:
water
diiodine
NADP(+)
Reactome.org link: R-HSA-350901