Reaction: Spermine => N-acetylated spermine
- in pathway: Interconversion of polyamines
Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).
Reaction - small molecule participants:
CoA-SH [cytosol]
NASPN [cytosol]
SPN [cytosol]
Ac-CoA [cytosol]
Reactome.org reaction link: R-HSA-351207
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Reaction input - small molecules:
spermine(4+)
acetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
N(1)-acetylsperminium(3+)
Reactome.org link: R-HSA-351207