Reaction: Spermidine => N-acetylated spermidine
- in pathway: Interconversion of polyamines
Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).
Reaction - small molecule participants:
NASPM [cytosol]
CoA-SH [cytosol]
SPM [cytosol]
Ac-CoA [cytosol]
Reactome.org reaction link: R-HSA-351208
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Reaction input - small molecules:
spermidine(3+)
acetyl-CoA(4-)
Reaction output - small molecules:
N(1)-acetylspermidine
coenzyme A(4-)
Reactome.org link: R-HSA-351208