Reaction: SLC6A18 transports Gly from extracellular region to cytosol
- in pathway: Na+/Cl- dependent neurotransmitter transporters
The protein SLC6A18 was first identified as an amino acid transporter based on sequence similarity to other members of the SLC6 protein family (Hoglund et al. 2005). It is annotated here as mediating glycine uptake based on the phenotype of mice homozygous for a null mutation in the homologous gene (Quan et al. 2004).
Reaction - small molecule participants:
Gly [cytosol]
Gly [extracellular region]
Gly [cytosol]
Gly [extracellular region]
Reactome.org reaction link: R-HSA-351963
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Reaction input - small molecules:
glycine zwitterion
glycine zwitterion
Reaction output - small molecules:
glycine zwitterion
glycine zwitterion
Reactome.org link: R-HSA-351963