Reaction: SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
- in pathway: Reuptake of GABA
The plasma membrane transport protein SLC6A12 (BGT-1) mediates the uptake of GABA (gamma-aminobutyrate) and betaine and, less efficiently, of diminobutyrate (DABA) and beta-alanine. Together with each amino acid molecule, 3 sodium ions and 2 chloride ions are taken up. In the body, SLC6A12 is expressed in the proximal tubules of the kidney and cells of the central nervous system (Rasola et al. 1995; Matskevitch et al. 1999).
Reaction - small molecule participants:
Na+ [cytosol]
Cl- [cytosol]
Cl- [extracellular region]
Na+ [extracellular region]
Na+ [cytosol]
Cl- [cytosol]
Cl- [extracellular region]
Na+ [extracellular region]
Na+ [cytosol]
Cl- [cytosol]
Cl- [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-352029
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Reaction input - small molecules:
chloride
sodium(1+)
chloride
sodium(1+)
chloride
sodium(1+)
Reaction output - small molecules:
sodium(1+)
chloride
sodium(1+)
chloride
sodium(1+)
chloride
Reactome.org link: R-HSA-352029