Reaction: Autophosphorylation of PTK2 at Y397
- in pathway: Integrin signaling
The co-localization of PTK2/FAK with integrins in focal adhesions and the actin cytoskeleton is essential for the activation and phosphorylation of PTK2/FAK.
PTK2/FAK has six tyrosine phosphorylation sites and tyrosine 397 is the main auto-phosphorylation site present upstream of the kinase domain.
PTK2/FAK has six tyrosine phosphorylation sites and tyrosine 397 is the main auto-phosphorylation site present upstream of the kinase domain.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-354073
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-354073