Reaction: Phosphorylation of pPTK2 by SRC
- in pathway: Integrin signaling
The recruitment of FADK1 to active SRC leads to the efficient tyrosine phosphorylation of multiple additional sites on FADK1. SRC trans-phosphorylates FADK1 within the kinase doman activation loop (Y576 and Y577) and within the FADK1 C-terminal domain (Y861 and Y925).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-354124
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-354124