Reaction: ATP7A transfers Cu from ATOX1 to SOD3
- in pathway: Detoxification of Reactive Oxygen Species
As inferred from mouse, ATP7A (Menke's ATPase, MNK) transports copper from ATOX in the cytosol to SOD3 in the lumen of the trans golgi network. ATP7A and SOD3 directly interact. Mutations in ATP7A cause Menke's disease, a neurodegenerative condition.
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
H2O [cytosol]
ATP [cytosol]
Zn2+ [Golgi lumen]
Reactome.org reaction link: R-HSA-3697838
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Reaction input - small molecules:
water
ATP(4-)
zinc(2+)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-3697838