Reaction: PRDX5 reduces peroxynitrite to nitrite using TXN
- in pathway: Detoxification of Reactive Oxygen Species
Peroxiredoxin 5 (PRDX5) very efficiently reduces peroxynitrite using thioredoxin to yield nitrite (NO2-), water, and oxidized thioredoxin (Dubuisson et al. 2004). The N-terminal cysteine (Cys 47) of PRDX5 attacks the O-O peroxide bond of peroxynitrite.
Reaction - small molecule participants:
H2O [cytosol]
Nitrite [cytosol]
Peroxynitrite [cytosol]
Reactome.org reaction link: R-HSA-3697882
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Reaction input - small molecules:
peroxynitrite
Reaction output - small molecules:
water
nitrite
Reactome.org link: R-HSA-3697882