Reaction: PRDX5 reduces peroxynitrite to nitrite using TXN2

- in pathway: Detoxification of Reactive Oxygen Species
Peroxiredoxin 5 (PRDX5) very efficiently reduces peroxynitrite using TXN2 in mitochodria to yield nitrite (NO2-), water, and oxidized TXN2 (Dubuisson et al. 2004). The N-terminal cysteine (Cys 47) of PRDX5 attacks the O-O peroxide bond of peroxynitrite.
Reaction - small molecule participants:
Nitrite [mitochondrial matrix]
H2O [mitochondrial matrix]
Peroxynitrite [mitochondrial matrix]
Reactome.org reaction link: R-HSA-3697894

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Reaction input - small molecules:
peroxynitrite
ChEBI:25941
Reaction output - small molecules:
nitrite
ChEBI:16301
water
ChEBI:15377
Reactome.org link: R-HSA-3697894