Reaction: AcCho is hydrolyzed to Cho and acetate by ACHE
- in pathway: Neurotransmitter clearance
Acetylcholinesterase (ACHE) oligomers (comprising monomers, dimers and tetramers), anchored to the extracellular side of the plasma membrane, hydrolyze acetylcholine (AcCho) to form choline (Cho) and acetate (Weinstock & Groner 2008, Velan et al. 1991, Kryger et al. 2000).
Acetylcholine from the synaptic cleft is degraded into inactive molecules, Cho and acetate by ACHE, which is located in the synaptic cleft (Weinstock & Groner 2008).
Acetylcholine from the synaptic cleft is degraded into inactive molecules, Cho and acetate by ACHE, which is located in the synaptic cleft (Weinstock & Groner 2008).
Reaction - small molecule participants:
acetate [extracellular region]
Cho [extracellular region]
H2O [extracellular region]
AcCho [extracellular region]
acetate [extracellular region]
Cho [extracellular region]
H2O [extracellular region]
AcCho [extracellular region]
Reactome.org reaction link: R-HSA-372519
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Reaction input - small molecules:
water
acetylcholine
water
acetylcholine
Reaction output - small molecules:
acetate
choline
acetate
choline
Reactome.org link: R-HSA-372519