Reaction: SLC25A10 mediates exchange of malate and phosphate
- in pathway: Gluconeogenesis
SLC25A10, the mitochondrial dicarboxylate carrier protein in the inner mitochondrial membrane, mediates the reversible exchange of mitochondrial malate for cytosolic phosphate (Fiermonte et al. 1999). Mutations in the human SLC25A10 gene disrupt malate transport and are associated with severe clinical phenotypes (Punzi et al. 2018).
Reaction - small molecule participants:
Pi [mitochondrial matrix]
MAL [cytosol]
Pi [cytosol]
MAL [mitochondrial matrix]
Pi [mitochondrial matrix]
MAL [cytosol]
Pi [cytosol]
MAL [mitochondrial matrix]
Reactome.org reaction link: R-HSA-372843
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Reaction input - small molecules:
hydrogenphosphate
(S)-malate(2-)
hydrogenphosphate
(S)-malate(2-)
Reaction output - small molecules:
hydrogenphosphate
(S)-malate(2-)
hydrogenphosphate
(S)-malate(2-)
Reactome.org link: R-HSA-372843