Reaction: G protein-coupled estrogen receptor 1 binds estrogen non-classically
- in pathway: Peptide ligand-binding receptors
G protein-coupled estrogen receptor 1 (GPER; CEPR; G-protein coupled receptor 30, GPR30) (Feng Y and Gregor P, 1997) has a ubiquitous tissue distribution. This orphan receptor is unrelated to nuclear estrogen receptors, but shows all the binding and signaling characteristics of a membrane estrogen receptor (mER). This suggests a role for GPCRs in nonclassical steroid hormone actions.
Reaction - small molecule participants:
ESTG [extracellular region]
Reactome.org reaction link: R-HSA-374207
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Reaction input - small molecules:
estrogen
Reaction output - small molecules:
Reactome.org link: R-HSA-374207