Reaction: Catabolism of Noradrenaline
- in pathway: Norepinephrine Neurotransmitter Release Cycle
Noradrenaline is degraded by Monoamine oxidase A, which contains FAD as a cofactor. Monoamine oxidase is located in the outer mitochondrial membrane facing the cytoplasm. Monoamine oxidase functions as a monomer and is functional both is astrocyes and neurons.
Reaction - small molecule participants:
3,4-dihydroxyphenylglycolaldehyde [cytoplasm]
NH3 [cytosol]
H2O2 [cytosol]
NAd [cytosol]
H2O [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-374909
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Reaction input - small molecules:
(R)-noradrenaline(1+)
water
dioxygen
Reaction output - small molecules:
3,4-dihydroxymandelaldehyde
ammonia
hydrogen peroxide
Reactome.org link: R-HSA-374909