Reaction: NCAM1 binds to ATP
- in pathway: NCAM1 interactions
NCAM1 has been demonstrated to possess (Ca++ or Mg++) dependant ATP hydrolyzing activity. ATP can bind to NCAM directly and that NCAM can act as an ecto-ATPase hydrolyzing around 1000 molecules of ATP/minute. Binding of ATP to NCAM1 inhibits cellular aggregation and neurite outgrowth induced by NCAM1-FGFR binding. The NCAM binding site to ATP overlaps with the site of NCAM-FGFR interaction, and ATP is capable of disrupting NCAM-FGFR binding.
Reaction - small molecule participants:
ATP [extracellular region]
Reactome.org reaction link: R-HSA-375160
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-375160