Reaction: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol
- in pathway: Na+/Cl- dependent neurotransmitter transporters
SLC6A19 mediates the uptake of neutral amino acids across the plasma membrane. Uptake of an amino acid molecule is accompanied by uptake of a sodium ion. The protein is abundant in cells in the small intestine and kidney. Its deficiency is associated with Hartnup disorder, the failure to take up neutral amino acids efficiently from the gut lumen and to reabsorb them in the proximal kidney tubule (Kleta et al. 2004, Seow et al. 2004).
Reaction - small molecule participants:
Na+ [cytosol]
Na+ [extracellular region]
Na+ [cytosol]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-375473
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Reaction input - small molecules:
sodium(1+)
sodium(1+)
Reaction output - small molecules:
sodium(1+)
sodium(1+)
Reactome.org link: R-HSA-375473