Reaction: SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol
- in pathway: Na+/Cl- dependent neurotransmitter transporters
SLC6A14, associated with the plasma membrane, mediates the uptake of multiple basic and nonpolar amino acids as well as beta-alanine. Uptake of one amino acid molecule is accompanied by uptake of two sodium ions and a chloride ion. As assessed by Northern blotting, SLC6A14 is expressed at high levels in lung but only at low levels, if at all, in intestine or kidney (Sloan & Mager 1999, Anderson et al. 2008).
Reaction - small molecule participants:
Na+ [cytosol]
Cl- [cytosol]
Cl- [extracellular region]
Na+ [extracellular region]
Na+ [cytosol]
Cl- [cytosol]
Cl- [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-375487
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Reaction input - small molecules:
chloride
sodium(1+)
chloride
sodium(1+)
Reaction output - small molecules:
sodium(1+)
chloride
sodium(1+)
chloride
Reactome.org link: R-HSA-375487