Reaction: AKT phosphorylates CBY1
- in pathway: Deactivation of the beta-catenin transactivating complex
CBY1 is phosphorylated in vitro at serine 20 by AKT1 and AKT2. In vivo, this phosphorylation is required for the export of beta-catenin from the nucleus, facilitated by the binding of 14-3-3/YWHAZ proteins to the pS20 residue of CBY1 (Li et al, 2008).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-3769394
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-3769394