Reaction: SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)
- in pathway: Detoxification of Reactive Oxygen Species
A portion of SOD1 is located in the mitochondrial intermembrane space (IMS) where it catalyzes the formation of oxygen (O2) and hydrogen peroxide (H2O2) from superoxide (O2.-) (He et al. 2011, Higgins et al. 2002, inferred from rat in Okado-Matsumoto and Fridovich 2001).
Reaction - small molecule participants:
H2O2 [mitochondrial intermembrane space]
O2 [mitochondrial intermembrane space]
O2- [mitochondrial intermembrane space]
H+ [mitochondrial intermembrane space]
Reactome.org reaction link: R-HSA-3777112
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Reaction input - small molecules:
superoxide
hydron
Reaction output - small molecules:
hydrogen peroxide
dioxygen
Reactome.org link: R-HSA-3777112