Reaction: H2O2 diffuses from the mitochondrial matrix to the cytosol
- in pathway: Detoxification of Reactive Oxygen Species
As inferred from rat heart mitochondria, hydrogen peroxide is released from mitochondria at a rate that is dependent on the membrane potential. Knockdown of Aquaporin-8 (AQP8) in human cells indicates that hydrogen peroxide is able to transit through the water channel of AQP8 located in the inner mitochodrial membrane (Marchissio et al. 2012). The resulting level of cytosolic hydrogen peroxide is hypothesized to signal the state of the mitochondria to regulatory molecules in the cytosol and nucleus (reviewed in Antico Arciuch et al. 2012).
Reaction - small molecule participants:
H2O2 [cytosol]
H2O2 [mitochondrial matrix]
Reactome.org reaction link: R-HSA-3779381
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Reaction input - small molecules:
hydrogen peroxide
Reaction output - small molecules:
hydrogen peroxide
Reactome.org link: R-HSA-3779381