Reaction: SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate
- in pathway: Amino acid transport across the plasma membrane
SLC7A11 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of glutamate and cysteine. Under physiological conditions, cytosolic glutamate concentrations are high and cysteine concentrations are low, so glutamate is exported and cysteine imported. SLC7A11 is widely expressed in the body (Bassi et al. 2001; Gasol et al. 2004).
Reaction - small molecule participants:
L-Glu [extracellular region]
L-Cys [cytosol]
L-Glu [cytosol]
Cys [extracellular region]
Reactome.org reaction link: R-HSA-378513
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Reaction input - small molecules:
L-glutamate(1-)
L-cysteine zwitterion
Reaction output - small molecules:
L-glutamate(1-)
L-cysteine zwitterion
Reactome.org link: R-HSA-378513