Reaction: SLC6A3 cotransports DA, Na+ from extracellular region to cytosol
- in pathway: Na+/Cl- dependent neurotransmitter transporters
The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.
Reaction - small molecule participants:
Na+ [cytosol]
DA [cytosol]
DA [extracellular region]
Na+ [extracellular region]
Na+ [cytosol]
DA [cytosol]
DA [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-379393
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Reaction input - small molecules:
dopaminium(1+)
sodium(1+)
dopaminium(1+)
sodium(1+)
Reaction output - small molecules:
sodium(1+)
dopaminium(1+)
sodium(1+)
dopaminium(1+)
Reactome.org link: R-HSA-379393