Reaction: MAOA:FAD deaminates 3MT to HVA
- in pathway: Enzymatic degradation of dopamine by COMT
3-methoxytyramine (3MT) generated by COMT after methylation of dopamine is oxidized into homovanillic acid (HVA) by monoamine oxidase A (MAOA), bound to its cofactor FAD (Guldberg et al. 1997).
Reaction - small molecule participants:
HVA [cytosol]
NH3 [cytosol]
H2O2 [cytosol]
3MT [cytosol]
H2O [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-379395
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Reaction input - small molecules:
3-methoxytyramine
water
dioxygen
Reaction output - small molecules:
homovanillic acid
ammonia
hydrogen peroxide
Reactome.org link: R-HSA-379395