Reaction: SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
- in pathway: Amino acid transport across the plasma membrane
SLC7A7 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of arginine (L-Arg) for leucine (L-Leu) and a sodium ion (Na+). The physiological concentrations of arginine and leucine are expected to favor arginine export. By the criterion of Northern blotting, SLC7A6 is predominantly expressed in the kidney (Pfeiffer et al. 2000).
Reaction - small molecule participants:
L-Arg [extracellular region]
Na+ [cytosol]
L-Leu [cytosol]
L-Arg [cytosol]
L-Leu [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-379415
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Reaction input - small molecules:
L-argininium(1+)
L-leucine zwitterion
sodium(1+)
Reaction output - small molecules:
L-argininium(1+)
sodium(1+)
L-leucine zwitterion
Reactome.org link: R-HSA-379415