Reaction: SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine
- in pathway: Amino acid transport across the plasma membrane
SLC7A6 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of arginine for leucine and a sodium ion. The physiological concentrations of arginine and leucine are expected to favor arginine export. By the criterion of Northern blotting, SLC7A6 is expressed in a variety of tissues (Broer et al. 2000).
Reaction - small molecule participants:
L-Arg [extracellular region]
Na+ [cytosol]
L-Leu [cytosol]
L-Arg [cytosol]
L-Leu [extracellular region]
Na+ [extracellular region]
Reactome.org reaction link: R-HSA-379426
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Reaction input - small molecules:
L-argininium(1+)
L-leucine zwitterion
sodium(1+)
Reaction output - small molecules:
L-argininium(1+)
sodium(1+)
L-leucine zwitterion
Reactome.org link: R-HSA-379426